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KMID : 0366220070420030292
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Korean Journal of Hematology
2007 Volume.42 No. 3 p.292 ~ p.295
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A Case of High Dose Cytosine Arabinoside Induced Stevens-Johnson Syndrome in a Patient with Malignant Lymphoma
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An Ji-Won
Lee Myung-Ah
Ko Yoon-Ho
Nam Sung-Min
Jung Mun-Kyung
Moon Su-Jin
Kang Jin-Hyoung
Hong Young-Seon
Lee Kyung-Sik
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Abstract
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Many chemotherapeutic agents induce variable cutaneous adverse reactions. Among the side effects, Stevens-Johnson syndrome is rare, but a fatal complication. There are two prior reports of cytosine arabinoside (ARA-C) induced toxic epidermal necrolysis, which is considered in the continuum of Stevens- Johnson syndrome. The prior cases were female patients under 16 years old with acute lymphocytic leukemia. We treated a 77-year-old man with recurrent mantle cell lymphoma who developed Stevens- Johnson syndrome after high dose ARA-C therapy. This is the first case of ARA-C induced Stevens- Johnson syndrome in Korea
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KEYWORD
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Stevens-Johnson syndrome, Cytosine arabinoside, Lymphoma
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